• Target：
• SYK

• Fields：
• >>Bile secretion;>>Choline metabolism in cancer

• Gene Name：
• SLC22A1

• Protein Name：
• Solute carrier family 22 member 1

• Human Gene Id：
• 6580

• Human Swiss Prot No：
• O15245

• Mouse Swiss Prot No：
• O08966

• Immunogen：
• Purified recombinant fragment of SYK (aa296-484) expressed in E. Coli.

• Specificity：
• SYK Monoclonal Antibody detects endogenous levels of SYK protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SLC22A1;OCT1;Solute carrier family 22 member 1;Organic cation transporter 1;hOCT1

• Molecular Weight(Da)：
• 61kD

• References：
• 1. Blood. 2006 Nov 15;108(10):3352-9
  2. Int J Mol Med. 2006 Oct;18(4):547-57.
  3. J Exp Med. 2006 Dec 25;203(13):2829-40.

• Background：
• Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008],

• Function：
• caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electroge

• Subcellular Location：
• Basolateral cell membrane ; Multi-pass membrane protein .

• Expression：
• Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.

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