• Target：
• SUZ12

• Gene Name：
• SUZ12

• Protein Name：
• Polycomb protein SUZ12

• Human Gene Id：
• 23512

• Human Swiss Prot No：
• Q15022

• Mouse Swiss Prot No：
• Q80U70

• Immunogen：
• Purified recombinant fragment of human SUZ12 expressed in E. Coli.

• Specificity：
• SUZ12 Monoclonal Antibody detects endogenous levels of SUZ12 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SUZ12;CHET9;JJAZ1;KIAA0160;Polycomb protein SUZ12;Chromatin precipitated E2F target 9 protein;ChET 9 protein;Joined to JAZF1 protein;Suppressor of zeste 12 protein homolog

• Molecular Weight(Da)：
• 83kD

• References：
• 1. Genes Dev. 2008 May 15;22(10):1345-55.
  2. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20001-6.

• Background：
• This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009],

• Function：
• caution:Two variants of the PRC2 complex have been described, termed PRC3 and PRC4. Each of the three complexes may include a different complement of EED isoforms, although the precise sequences of the isoforms in each complex have not been determined. The PRC2 and PRC4 complexes may also methylate 'Lys-26' of histone H1 in addition to 'Lys-27' of histone H3 (PubMed:15099518 and PubMed:15684044), although other studies have demonstrated no methylation of 'Lys-26' of histone H1 by PRC2 (PubMed:16431907).,developmental stage:Expressed at low levels in quiescent cells. Expression rises at the G1/S phase transition.,disease:A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is freque

• Subcellular Location：
• Nucleus . Localizes to chromatin as part of the PRC2 complex. .

• Expression：
• Overexpressed in breast and colon cancer.

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