• Target：
• Msi1

• Fields：
• >>mRNA surveillance pathway

• Gene Name：
• MSI1

• Protein Name：
• RNA-binding protein Musashi homolog 1

• Human Gene Id：
• 4440

• Human Swiss Prot No：
• O43347

• Mouse Swiss Prot No：
• Q61474

• Immunogen：
• Purified recombinant fragment of human Msi1 expressed in E. Coli.

• Specificity：
• Msi1 Monoclonal Antibody detects endogenous levels of Msi1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MSI1;RNA-binding protein Musashi homolog 1;Musashi-1

• Molecular Weight(Da)：
• 39kD

• References：
• 1. BMC Cancer. 2008 Apr 18;8:108.
  2. Gastroenterology. 2008 May;134(5):1448-58.

• Background：
• This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008],

• Function：
• domain:The first RNA recognition motif binds more strongly to RNA compared to the second one.,function:RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.,similarity:Belongs to the Musashi family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,tissue specificity:Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.,

• Subcellular Location：
• Cytoplasm . Nucleus .

• Expression：
• Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.

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