• Target：
• MOF

• Gene Name：
• KAT8

• Protein Name：
• Histone acetyltransferase KAT8

• Human Gene Id：
• 84148

• Human Swiss Prot No：
• Q9H7Z6

• Mouse Swiss Prot No：
• Q9D1P2

• Immunogen：
• Purified recombinant fragment of human MOF expressed in E. Coli.

• Specificity：
• MOF Monoclonal Antibody detects endogenous levels of MOF protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• KAT8;MOF;MYST1;PP7073;Histone acetyltransferase KAT8;Lysine acetyltransferase 8;MOZ; YBF2/SAS3, SAS2 and TIP60 protein 1;MYST-1;hMOF

• Molecular Weight(Da)：
• 52kD

• References：
• 1. Sterner, D.E., et al. Microbiol. Mol. Biol 2000 Rev. 64: 435-459.
  2. Neal, K.C., et al. Biochim. Biophys. 2000 Acta 1490: 170-174.
  3. Akhtar, A., et al. EMBO 2001 Rep. 2: 113-118.

• Background：
• This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012],

• Function：
• catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,function:Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM.,similarity:Belongs to the MYST (SAS/MOZ) family.,similarity:Contains 1 C2HC-type zinc finger.,similarity:Contains 1 chromo domain.,subunit:Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/MYST1, MSL1/hampin, MSL2L1 and MSL3L1. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM through the chromodomain.,

• Subcellular Location：
• Nucleus . Chromosome .

• Expression：
• Brain,Embryo,Heart,Uterus,

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