• Target：
• I-FABP

• Fields：
• >>PPAR signaling pathway;>>Fat digestion and absorption

• Gene Name：
• FABP2

• Protein Name：
• Fatty acid-binding protein, intestinal

• Human Gene Id：
• 2169

• Human Swiss Prot No：
• P12104

• Mouse Swiss Prot No：
• P55050

• Immunogen：
• Purified recombinant fragment of human I-FABP expressed in E. Coli.

• Specificity：
• I-FABP Monoclonal Antibody detects endogenous levels of I-FABP protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• FABP2;FABPI;Fatty acid-binding protein; intestinal;Fatty acid-binding protein 2;Intestinal-type fatty acid-binding protein;I-FABP

• Molecular Weight(Da)：
• 15kD

• References：
• 1. Yamada, K. et al. (1997) Diabetologia. 40(6):706-10
  2. Georgopoulos, A. et al. (2000)85(9):3155-60
  3. Kim, CH. et al. (2001) Metabolism. 50(4):473-6
  4. Fisher, E. et al. (2006) Horm Met

• Background：
• The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008],

• Function：
• domain:Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.,function:FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.,induction:By EGF.,similarity:Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.,tissue specificity:Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.,

• Subcellular Location：
• Cytoplasm.

• Expression：
• Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.

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