• Target：
• GDF-8

• Fields：
• >>Cytokine-cytokine receptor interaction

• Gene Name：
• MSTN

• Protein Name：
• Growth/differentiation factor 8

• Human Gene Id：
• 2660

• Human Swiss Prot No：
• O14793

• Mouse Swiss Prot No：
• O08689

• Immunogen：
• Purified recombinant fragment of GDF-8 expressed in E. Coli.

• Specificity：
• GDF-8 Monoclonal Antibody detects endogenous levels of GDF-8 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MSTN;GDF8;Growth/differentiation factor 8;GDF-8;Myostatin

• Molecular Weight(Da)：
• 43kD

• References：
• 1. Clin Chim Acta. 2008 May;391(1-2):115-7.
  2. Folia Morphol (Warsz). 2008 Feb;67(1):6-12.

• Background：
• myostatin(MSTN) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016],

• Function：
• function:Acts specifically as a negative regulator of skeletal muscle growth.,online information:Myostatin entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity.,

• Subcellular Location：
• Secreted .

• Expression：
• Colon,Muscle,Pericardium,Skeletal muscle,

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