• Target：
• GATA-1

• Gene Name：
• GATA1

• Protein Name：
• Erythroid transcription factor

• Human Gene Id：
• 2623

• Human Swiss Prot No：
• P15976

• Mouse Swiss Prot No：
• P17679

• Immunogen：
• Purified recombinant fragment of human GATA-1 expressed in E. Coli.

• Specificity：
• GATA-1 Monoclonal Antibody detects endogenous levels of GATA-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GATA1;ERYF1;GF1;Erythroid transcription factor;Eryf1;GATA-binding factor 1;GATA-1;GF-1;NF-E1 DNA-binding protein

• Molecular Weight(Da)：
• 43kD

• References：
• 1. Cancer Res. 2009 Apr 15;69(8):3681-8.
  2. J Bone Miner Res. 2009 Dec;24(12):2039-49.
  3. Blood. 2010 Jun 3;115(22):4367-76.

• Background：
• This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.,disease:Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050]; also called thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis. The disease consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced (hemo)globin chain synthesis resembling that of beta-thalassemia minor.,domain:The two fingers are functionally distinct and cooperate to achie

• Subcellular Location：
• Nucleus.

• Expression：
• Erythrocytes.

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