• Target：
• ETS1

• Fields：
• >>Ras signaling pathway;>>Cellular senescence;>>Human T-cell leukemia virus 1 infection;>>Pathways in cancer;>>Renal cell carcinoma

• Gene Name：
• ETS1

• Protein Name：
• Protein C-ets-1

• Human Gene Id：
• 2113

• Human Swiss Prot No：
• P14921

• Mouse Swiss Prot No：
• P27577

• Immunogen：
• Purified recombinant fragment of human ETS1 expressed in E. Coli.

• Specificity：
• ETS1 Monoclonal Antibody detects endogenous levels of ETS1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ETS1;EWSR2;Protein C-ets-1;p54

• Molecular Weight(Da)：
• 50kD

• References：
• 1. DNA Cell Biol. 2005 Feb;24(2):126-32.
  2. Mol Hum Reprod. 2006 Feb;12(2):71-6.
  3. J Biol Chem. 2008 Jan 11;283(2):951-62.
  

• Background：
• This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011],

• Function：
• disease:ETS is responsible for erythroblast and fibroblast transformation. The juxtaposition of the interferon and c-ETS-1 proto-oncogene may be involved in the pathogenesis of human monocytic leukemia.,function:Transcription factor.,PTM:Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity.,PTM:Ubiquitinated; which induces proteasomal degradation.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Interacts with MAF and MAFB (By similarity). Binds to DAXX. Interacts with UBE2I.,

• Subcellular Location：
• Cytoplasm . Nucleus . Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. .

• Expression：
• Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.

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