• Target：
• EphA8

• Fields：
• >>Axon guidance

• Gene Name：
• EPHA8

• Protein Name：
• Ephrin type-A receptor 8

• Human Gene Id：
• 2046

• Human Swiss Prot No：
• P29322

• Mouse Swiss Prot No：
• O09127

• Immunogen：
• Purified recombinant fragment of EphA8 (aa70-150) expressed in E. Coli.

• Specificity：
• EphA8 Monoclonal Antibody detects endogenous levels of EphA8 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• EPHA8;EEK;HEK3;KIAA1459;Ephrin type-A receptor 8;EPH- and ELK-related kinase;EPH-like kinase 3;EK3;hEK3;Tyrosine-protein kinase receptor EEK

• Molecular Weight(Da)：
• 111kD

• References：
• 1. Curr Opin Neurobiol. 2004 Jun;14(3):288-96.
  2. Oncogene. 2005 Jun 16;24(26):4243-56.

• Background：
• This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family.,PTM:Phosphorylation on Tyr-616 is critical for association with FYN.,PTM:Phosphorylation on Tyr-839 modulates tyrosine kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with FYN (By similarity). Interacts with ANKS1B.,

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein . Cell projection . Early endosome membrane . Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes. .

• Expression：
• Brain,Eye,

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