• Target：
• EPHA7

• Fields：
• >>Axon guidance

• Gene Name：
• EPHA7

• Protein Name：
• Ephrin type-A receptor 7

• Human Gene Id：
• 2045

• Human Swiss Prot No：
• Q15375

• Mouse Swiss Prot No：
• Q61772

• Immunogen：
• Purified recombinant fragment of EphA7 (aa27-210) expressed in E. Coli.

• Specificity：
• EphA7 Monoclonal Antibody detects endogenous levels of EphA7 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• EPHA7;EHK3;HEK11;Ephrin type-A receptor 7;EPH homology kinase 3;EHK-3;EPH-like kinase 11;EK11;hEK11

• Molecular Weight(Da)：
• 112kD

• References：
• 1. Genome Res. 2004 Oct;14(10B):2121-7.
  2. Nature. 2005 Oct 20;437(7062):1173-8.

• Background：
• This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with PRKCABP and GRIP1.,tissue specificity:Widely expressed.,

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Widely expressed.

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