• Target：
• EphA1

• Fields：
• >>Axon guidance

• Gene Name：
• EPHA1

• Protein Name：
• Ephrin type-A receptor 1

• Human Gene Id：
• 2041

• Human Swiss Prot No：
• P21709

• Mouse Swiss Prot No：
• Q60750

• Immunogen：
• Purified recombinant fragment of EphA1 expressed in E. Coli.

• Specificity：
• EphA1 Monoclonal Antibody detects endogenous levels of EphA1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• EPHA1;EPH;EPHT;EPHT1;Ephrin type-A receptor 1;hEpha1;EPH tyrosine kinase;EPH tyrosine kinase 1;Erythropoietin-producing hepatoma receptor;Tyrosine-protein kinase receptor EPH

• Molecular Weight(Da)：
• 108kD

• References：
• 1. Shannon L. Duffy, Kirsten A. Steiner, Patrick P.L. Tam Gene Expr Patterns. 2006 Feb 6.
  2. Elena B. Pasquale. Nat Rev Mol Cell Biol.2005 Jun; 6(6): 462-75.

• Background：
• This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family. Binds with a low affinity to ephrin-A1.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Overexpressed in several carcinomas.,

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Overexpressed in several carcinomas.

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