• Target：
• Cripto

• Gene Name：
• TDGF1

• Protein Name：
• Teratocarcinoma-derived growth factor 1

• Human Gene Id：
• 6997

• Human Swiss Prot No：
• P13385

• Mouse Swiss Prot No：
• P51865

• Immunogen：
• Purified recombinant fragment of human Cripto expressed in E. Coli.

• Specificity：
• Cripto Monoclonal Antibody detects endogenous levels of Cripto protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TDGF1;CRIPTO;Teratocarcinoma-derived growth factor 1;Cripto-1 growth factor;CRGF;Epidermal growth factor-like cripto protein CR1

• Molecular Weight(Da)：
• 21kD

• References：
• 1. Histopathology. 2008 Apr;52(5):560-8.
  2. J Biol Chem. 2008 Feb 22;283(8):4490-500.

• Background：
• This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],

• Function：
• function:Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.,similarity:Contains 1 EGF-like domain.,tissue specificity:Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts.,

• Subcellular Location：
• Cell membrane ; Lipid-anchor, GPI-anchor . Secreted . Released from the cell membrane by GPI cleavage. .

• Expression：
• Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

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