• Target：
• CD71/TfR

• Fields：
• >>HIF-1 signaling pathway;>>Endocytosis;>>Phagosome;>>Ferroptosis;>>Hematopoietic cell lineage

• Gene Name：
• TFR1

• Protein Name：
• Transferrin receptor protein 1

• Human Gene Id：
• 4155

• Human Swiss Prot No：
• P02786

• Mouse Swiss Prot No：
• Q62351

• Immunogen：
• Purified recombinant fragment of human CD71 expressed in E. Coli.

• Specificity：
• CD71 Monoclonal Antibody detects endogenous levels of CD71 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TFRC;Transferrin receptor protein 1;TR;TfR;TfR1;Trfr;T9;p90;CD antigen CD71

• Molecular Weight(Da)：
• 85kD

• References：
• 1. Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1651-8.
  2. Biochemistry. 2009 Jun 9;48(22):4720-7.

• Background：
• This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],

• Function：
• function:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.,induction:Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.,miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use t

• Subcellular Location：
• Cell membrane ; Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .; [Transferrin receptor protein 1, serum form]: Secreted .

• Expression：
• Brain,Epithelium,Erythroleukemia,Eye,Human endometrium carcinoma cell line,Liver,Pl

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