CD4 Monoclonal Antibody

    • Catalog No.：YM0124
    • Applications：FCM;ELISA
    • Reactivity：Human
      • Target：
      • CD4
      • Fields：
      • >>Viral life cycle - HIV-1;>>Cytokine-cytokine receptor interaction;>>Cell adhesion molecules;>>Antigen processing and presentation;>>Hematopoietic cell lineage;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>Yersinia infection;>>Human T-cell leukemia virus 1 infection;>>Human immunodeficiency virus 1 infection;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Primary immunodeficiency
      • Gene Name：
      • CD4
      • Protein Name：
      • T-cell surface glycoprotein CD4
      • Human Gene Id：
      • 920
      • Human Swiss Prot No：
      • P01730
      • Mouse Swiss Prot No：
      • P06332
      • Immunogen：
      • Purified recombinant fragment of human CD4 expressed in E. Coli.
      • Specificity：
      • CD4 Monoclonal Antibody detects endogenous levels of CD4 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Concentration：
      • 0.5 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • CD4;T-cell surface glycoprotein CD4;T-cell surface antigen T4/Leu-3;CD antigen CD4
      • References：
      • 1. M Benkirane J Virol. 1995 November; 69(11): 6898–6903.
      • Background：
      • This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010],
      • Function：
      • function:Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.,miscellaneous:Primary receptor for HIV-1.,online information:CD4 entry,PTM:Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.,subunit:Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to t
      • Subcellular Location：
      • Cell membrane ; Single-pass type I membrane protein . Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
      • Expression：
      • Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.
      • Products Images
      • Flow cytometric analysis of blood T cells using CD4 Monoclonal Antibody (M2) and negative control (M1).

      Attributes

      • Code：
      • YM0124
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-11-30
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