• Target：
• CD10

• Fields：
• >>Renin-angiotensin system;>>Hematopoietic cell lineage;>>Protein digestion and absorption;>>Alzheimer disease

• Gene Name：
• MME

• Protein Name：
• Neprilysin

• Human Gene Id：
• 4311

• Human Swiss Prot No：
• P08473

• Mouse Swiss Prot No：
• Q61391

• Immunogen：
• Purified recombinant fragment of CD10 expressed in E. Coli.

• Specificity：
• CD10 Monoclonal Antibody detects endogenous levels of CD10 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MME;EPN;Neprilysin;Atriopeptidase;Common acute lymphocytic leukemia antigen;CALLA;Enkephalinase;Neutral endopeptidase 24.11;NEP;Neutral endopeptidase;Skin fibroblast elastase;SFE;CD antigen CD10

• Molecular Weight(Da)：
• 86kD

• References：
• 1. Journal of Gastroenterology,1996 Feb.31(1):12-7.
  2. British Journal of Haematology,1995,89(3):623-6.

• Background：
• This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this

• Function：
• catalytic activity:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.,cofactor:Binds 1 zinc ion per subunit.,disease:Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.,enzyme regulation:Inhibited in a dose dependent manner by opiorphin.,function:Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF).,similarity:Belongs to the peptidase M13 family.,

• Subcellular Location：
• Cell membrane; Single-pass type II membrane protein.

• Expression：
• Adrenal cortex,Brain,Kidney,Placenta,

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