FoxO4 (Acetyl Lys189) Polyclonal Antibody

    • Catalog No.:YK0078
    • Applications:WB;ELISA
    • Reactivity:Human;Rat;Mouse;
      • Target:
      • FoxO4
      • Fields:
      • >>Ras signaling pathway;>>FoxO signaling pathway;>>Shigellosis
      • Gene Name:
      • FOXO4 AFX AFX1 MLLT7
      • Protein Name:
      • Forkhead box protein O4 (Fork head domain transcription factor AFX1)
      • Human Gene Id:
      • 4303
      • Human Swiss Prot No:
      • P98177
      • Mouse Swiss Prot No:
      • Q9WVH3
      • Immunogen:
      • Synthetic Acetyl peptide from human protein at AA range: 189
      • Specificity:
      • The antibody detects endogenous FoxO4 when Acetyl occurs at Lys189
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000, ELISA 1:10000-20000
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • Forkhead box protein O4 (Fork head domain transcription factor AFX1)
      • Observed Band(KD):
      • 55kD
      • Background:
      • This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010],
      • Function:
      • disease:A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with MLL/HRX. The result is a rogue activator protein.,function:Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.,pharmaceutical:A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity.,PTM:Acetylation by CBP, which is induced by peroxidase stress, inhibits transcriptional activity. Dea
      • Subcellular Location:
      • Cytoplasm. Nucleus. When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
      • Expression:
      • Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.
      • Products Images
      • Western blot analysis of 3T3 mouse-kidney KB K562 Hela lysate, antibody was diluted at 500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000