• Gene Name：
• MAP2K4

• Protein Name：
• MEK4 protein

• Sequence：
• Amino acid: 218-362, with his-MBP tag.

• Human Gene Id：
• 6416

• Human Swiss Prot No：
• P45985

• Mouse Swiss Prot No：
• P47809

• Formulation：
• Liquid in PBS

• Source：
• E.coli

• Dilution：
• WB 1:500-2000

• Concentration：
• SDS-PAGE >90%

• Storage Stability：
• -20°C/6 month,-80°C for long storage

• Other Name：
• Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK)

• Background：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).,PTM:Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with SPAG9.,tissue specificity:Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.,

• Function：
• MAPKKK cascade, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process,intracellular signaling cascade, protein kinase cascade, JNK cascade, phosphorylation, stress-activated protein kinase signaling pathway, cellular response to stress,

• Subcellular Location：
• Cytoplasm . Nucleus .

• Expression：
• Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

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