JAK1 protein

    • Catalog No.：YD0054
    • Applications：WB;SDS-PAGE
    • Reactivity：Human
      • Gene Name：
      • JAK1
      • Protein Name：
      • JAK1 protein
      • Sequence：
      • Amino acid: 1-189, with his-MBP tag.
      • Human Gene Id：
      • 3716
      • Human Swiss Prot No：
      • P23458
      • Mouse Swiss Prot No：
      • P52332
      • Formulation：
      • Liquid in PBS
      • Source：
      • E.coli
      • Dilution：
      • WB 1:500-2000
      • Concentration：
      • SDS-PAGE >90%
      • Storage Stability：
      • -20°C/6 month,-80°C for long storage
      • Other Name：
      • Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
      • Background：
      • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Wholly intracellular, possibly membrane associated.,subunit:Interacts with IL31RA, JAKMIP1 and SHB.,tissue specificity:Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.,
      • Function：
      • protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, intracellular signaling cascade,protein kinase cascade, phosphorylation, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, cytokine-mediated signaling pathway, response to antibiotic,
      • Subcellular Location：
      • Endomembrane system; Peripheral membrane protein. Wholly intracellular, possibly membrane associated.
      • Expression：
      • Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
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      Attributes

      • Code：
      • YD0054
      • Size
      • 100μg
      • Price$：
      • 280
      • Delivery：
      • 2024-08-22
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