HSC70 protein

    • Catalog No.：YD0040
    • Applications：WB;SDS-PAGE
    • Reactivity：Human
      • Gene Name：
      • HSPA8
      • Protein Name：
      • HSC70 protein
      • Sequence：
      • Amino acid: 419-601, with his-MBP tag.
      • Human Gene Id：
      • 3312
      • Human Swiss Prot No：
      • P11142
      • Mouse Swiss Prot No：
      • P63017
      • Formulation：
      • Liquid in PBS
      • Source：
      • E.coli
      • Dilution：
      • WB 1:500-2000
      • Concentration：
      • SDS-PAGE >90%
      • Storage Stability：
      • -20°C/6 month,-80°C for long storage
      • Other Name：
      • Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)
      • Background：
      • function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.,induction:Constitutively synthesized.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Interacts with PACRG and TSC2. Interacts with SV40 VP1.,tissue specificity:Ubiquitous.,
      • Function：
      • protein folding, 'de novo' protein folding, post-Golgi vesicle-mediated transport, response to unfolded protein,response to organic substance, membrane organization, vesicle-mediated transport, intracellular transport, Golgi vesicle transport, 'de novo' posttranslational protein folding, chaperone mediated protein folding requiring cofactor,regulation of cell cycle, response to protein stimulus,
      • Subcellular Location：
      • Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
      • Expression：
      • Ubiquitous.
      • Products Images

      Attributes

      • Code：
      • YD0040
      • Size
      • 100μg
      • Price$：
      • 280
      • Delivery：
      • 2024-08-22
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