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- ERK3 protein
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ERK3 protein
- Catalog No.:YD0030
- Applications:WB;SDS-PAGE
- Reactivity:Human
- Protein Name:
- ERK3 protein
- Sequence:
- Amino acid: 538-721, with his-MBP tag.
- Formulation:
- Liquid in PBS
- Concentration:
- SDS-PAGE >90%
- Storage Stability:
- -20°C/6 month,-80°C for long storage
- Other Name:
- Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK)
- Background:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation.,function:Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.,PTM:Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.,
- Function:
- protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell cycle,phosphorylation,
- Subcellular Location:
- Cytoplasm . Nucleus . Translocates to the cytoplasm following interaction with MAPKAPK5. .
- Expression:
- Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.