CATB (Cleaved-Asn126) rabbit pAb

  • Catalog No.：YC0121
  • Applications：WB;ELISA
  • Reactivity：Human;Rat;Mouse;
    • Target：
    • CATB
    • Fields：
    • >>Autophagy - animal;>>Lysosome;>>Apoptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>Renin secretion
    • Gene Name：
    • CTSB CPSB
    • Protein Name：
    • CATB (Cleaved-Asn126)
    • Human Gene Id：
    • 1508
    • Human Swiss Prot No：
    • P07858
    • Mouse Swiss Prot No：
    • P10605
    • Immunogen：
    • Synthesized peptide derived from human CATB (Cleaved-Asn126)
    • Specificity：
    • This antibody detects endogenous levels of Human CATB (Cleaved-Asn126, protein was cleaved amino acid sequence between 126-127 )
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:1000-2000 ELISA 1:5000-20000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Cathepsin B (EC 3.4.22.1;APP secretase;APPS;Cathepsin B1) [Cleaved into: Cathepsin B light chain;Cathepsin B heavy chain]
    • Observed Band(KD)：
    • 15 37kD
    • Background：
    • catalytic activity:Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.,function:Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.,similarity:Belongs to the peptidase C1 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.,
    • Function：
    • proteolysis, response to wounding, regulation of cell death, regulation of apoptosis, regulation of programmed cell death,
    • Subcellular Location：
    • Lysosome . Melanosome . Secreted, extracellular space . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity). .
    • Expression：
    • Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum.

    Attributes

    • Code：
    • YC0121
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-07-17
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