• Target：
• SUMO-2/3

• Fields：
• >>Nucleocytoplasmic transport;>>Fluid shear stress and atherosclerosis

• Gene Name：
• SUMO2 SUMO3

• Protein Name：
• Small ubiquitin-related modifier 2

• Human Gene Id：
• 6613

• Human Swiss Prot No：
• P61956/P55854

• Mouse Gene Id：
• 170930

• Mouse Swiss Prot No：
• P61957

• Rat Gene Id：
• 690244

• Rat Swiss Prot No：
• P61959

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human SUMO2/3. AA range:44-93

• Specificity：
• Cleaved-SUMO-2/3 (G93) Polyclonal Antibody detects endogenous levels of fragment of activated SUMO-2/3 protein resulting from cleavage adjacent to G93.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. IP 1:50-100 Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SUMO2;SMT3A;SMT3H2;Small ubiquitin-related modifier 2;SUMO-2;HSMT3;SMT3 homolog 2;SUMO-3;Sentrin-2;Ubiquitin-like protein SMT3A;Smt3A

• Observed Band(KD)：
• 11kD

• Background：
• This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

• Function：
• function:Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.,online information:SUMO protein entry,PTM:Cleavage of precursor form by SENP1 or SENP2 is necessary for function.,PTM:Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.,PTM:Polymeric chains can be formed through Lys-11 cross-linking.,similarity:Belongs to the ubiquitin family. S

• Subcellular Location：
• Nucleus. Nucleus, PML body.

• Expression：
• Broadly expressed.

SENP6-Mediated deSUMOylation of VEGFR2 Enhances Its Cell Membrane Transport in Angiogenesis INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Xiaohua Guo WB,CoIP Human human umbilical vein endothelial cells (HUVECs)

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