• Target：
• Ephrin-A2

• Fields：
• >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>PI3K-Akt signaling pathway;>>Axon guidance;>>MicroRNAs in cancer

• Gene Name：
• EFNA2

• Protein Name：
• Ephrin-A2

• Human Gene Id：
• 1943

• Human Swiss Prot No：
• O43921

• Mouse Gene Id：
• 13637

• Mouse Swiss Prot No：
• P52801

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human EFNA2. AA range:139-188

• Specificity：
• Cleaved-Ephrin-A2 (N188) Polyclonal Antibody detects endogenous levels of fragment of activated Ephrin-A2 protein resulting from cleavage adjacent to N188.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• EFNA2;EPLG6;LERK6;Ephrin-A2;EPH-related receptor tyrosine kinase ligand 6;LERK-6;HEK7 ligand;HEK7-L

• Observed Band(KD)：
• 21kD

• Background：
• This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008],

• Function：
• similarity:Belongs to the ephrin family.,subunit:Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5.,

• Subcellular Location：
• Cell membrane ; Lipid-anchor, GPI-anchor .

• Expression：
• Brain,

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