Cleaved-Cathepsin D LC (G65) Polyclonal Antibody

    • Catalog No.：YC0038
    • Applications：WB;ELISA
    • Reactivity：Human;Monkey
      • Target：
      • Cathepsin D
      • Fields：
      • >>Sphingolipid signaling pathway;>>Autophagy - animal;>>Lysosome;>>Apoptosis;>>Estrogen signaling pathway;>>Tuberculosis;>>Diabetic cardiomyopathy
      • Gene Name：
      • CTSD
      • Protein Name：
      • Cathepsin D
      • Human Gene Id：
      • 1509
      • Human Swiss Prot No：
      • P07339
      • Mouse Swiss Prot No：
      • P18242
      • Immunogen：
      • The antiserum was produced against synthesized peptide derived from human CATD. AA range:46-95
      • Specificity：
      • Cleaved-Cathepsin D LC (G65) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin D LC protein resulting from cleavage adjacent to G65.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • CTSD;CPSD;Cathepsin D
      • Observed Band(KD)：
      • 17kD
      • Background：
      • This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015],
      • Function：
      • catalytic activity:Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.,disease:Defects in CTSD are the cause of neuronal ceroid lipofuscinosis 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. The neuronal ceroid lipofuscinosis are a group of progressive neurodegenerative diseases in children and in adults, characterized by visual and mental decline, motor disturbance, epilepsy and behavioral changes.,function:Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.,polymorphism:The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for de
      • Subcellular Location：
      • Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). .
      • Expression：
      • Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
      • Products Images
      • Western Blot analysis of various cells using Cleaved-Cathepsin D LC (G65) Polyclonal Antibody

      Attributes

      • Code：
      • YC0038
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-11-24
      Order

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