• Gene Name：
• THBD

• Protein Name：
• Thrombomodulin

• Human Gene Id：
• 7056

• Human Swiss Prot No：
• P07204

• Mouse Swiss Prot No：
• P15306

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• THBD;THRM;Thrombomodulin;TM;Fetomodulin;CD antigen CD141

• Detection Method：
• Colorimetric

• Background：
• disease:Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBDD) [MIM:188040]. THR-THBDD is a hemostatic disorder characterized by a tendency to thrombosis.,function:Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.,online information:Thrombomodulin,online information:Thrombomodulin entry,PTM:N-glycosylated.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 6 EGF-like domains.,tissue specificity:Endothelial cells are unique in synthesizing thrombomodulin.,

• Function：
• response to molecule of bacterial origin, female pregnancy, blood coagulation, hemostasis, response to radiation,response to wounding, response to bacterium, response to abiotic stimulus, response to organic substance, response to X-ray, response to ionizing radiation, response to lipopolysaccharide, wound healing, coagulation, regulation of body fluid levels, response to cAMP,

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

• Expression：
• Endothelial cells are unique in synthesizing thrombomodulin.

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