• Gene Name：
• PCSK9

• Protein Name：
• Proprotein convertase subtilisin/kexin type 9

• Human Gene Id：
• 255738

• Human Swiss Prot No：
• Q8NBP7

• Mouse Swiss Prot No：
• Q80W65

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• PCSK9;NARC1;PSEC0052;Proprotein convertase subtilisin/kexin type 9;Neural apoptosis-regulated convertase 1;NARC-1;Proprotein convertase 9;PC9;Subtilisin/kexin-like protease PC9

• Detection Method：
• Colorimetric

• Background：
• cofactor:Calcium.,disease:Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.,enzyme regulation:Inhibited by EGTA.,function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.,PTM:The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.,similarity:Belongs to the peptidase S8 family.,similarity:Contains 1 peptidase S8 domain.,subunit:The precursor protein but not the mature protein may form multimers.,tissue specificity:Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.,

• Function：
• urogenital system development, kidney development, liver development, regulation of receptor recycling, negative regulation of receptor recycling, regulation of receptor internalization, positive regulation of receptor internalization,proteolysis, neutral lipid metabolic process, acylglycerol metabolic process, triglyceride metabolic process, phospholipid metabolic process, glycerol ether metabolic process, induction of apoptosis, vacuolar transport, lysosomal transport,steroid metabolic process, cholesterol metabolic process, macromolecule catabolic process, cellular response to starvation, response to endogenous stimulus, response to hormone stimulus, regulation of catabolic process,response to extracellular stimulus, response to organic substance, regulation of receptor activity, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic pro

• Subcellular Location：
• Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation.

• Expression：
• Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

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