• Gene Name：
• SPP1

• Protein Name：
• Osteopontin

• Human Gene Id：
• 6696

• Human Swiss Prot No：
• P10451

• Mouse Swiss Prot No：
• P10923

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• SPP1;BNSP;OPN;PSEC0156;Osteopontin;Bone sialoprotein 1;Nephropontin;Secreted phosphoprotein 1;SPP-1;Urinary stone protein;Uropontin

• Detection Method：
• Colorimetric

• Background：
• disease:This protein plays a principal role in urinary stone formation as the stone matrix.,function:Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.,function:Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.,online information:Osteopontin entry,PTM:Extensively phosphorylated on clustered serine residues.,PTM:N- and O-glycosylated.,similarity:Belongs to the osteopontin family.,subunit:Ligand for integrin alpha-V/beta-3.,

• Function：
• skeletal system development, ossification, regulation of cell growth, osteoblast differentiation, placenta development,maternal placenta development, reproductive developmental process, defense response, inflammatory response, cell adhesion, female pregnancy, embryo implantation, response to nutrient, regulation of cell size, response to wounding,response to endogenous stimulus, response to hormone stimulus, response to extracellular stimulus, response to organic substance, negative regulation of cell development, regulation of cell morphogenesis involved in differentiation, regulation of cell-substrate adhesion, positive regulation of cell-substrate adhesion, regulation of neuron projection development, negative regulation of neuron projection development, regulation of cell morphogenesis, biological adhesion, regulation of cell adhesion, negative regulation of cell growth, biomineral f

• Subcellular Location：
• Secreted.

• Expression：
• Bone. Found in plasma.

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