• Gene Name：
• MSLN

• Protein Name：
• Mesothelin

• Human Gene Id：
• 10232

• Human Swiss Prot No：
• Q13421

• Mouse Swiss Prot No：
• Q61468

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• MSLN;MPF;Mesothelin;CAK1 antigen;Pre-pro-megakaryocyte-potentiating factor

• Detection Method：
• Colorimetric

• Background：
• disease:Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.,function:Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.,function:Membrane-anchored forms may play a role in cellular adhesion.,PTM:Both MPF and the cleaved form of mesothelin are N-glycosylated.,PTM:Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.,similarity:Belongs to the mesothelin family.,subunit:Interacts with MUC16.,tissue specificity:Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).,

• Function：
• cell adhesion, biological adhesion,

• Subcellular Location：
• Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.; [Megakaryocyte-potentiating factor]: Secreted.; [Isoform 3]: Secreted.

• Expression：
• Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).

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