• Gene Name：
• FOLR1

• Protein Name：
• Folate receptor alpha

• Human Gene Id：
• 2348

• Human Swiss Prot No：
• P15328

• Mouse Swiss Prot No：
• P35846

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• FOLR1;FOLR;Folate receptor alpha;FR-alpha;Adult folate-binding protein;FBP;Folate receptor 1;Folate receptor; adult;KB cells FBP;Ovarian tumor-associated antigen MOv18

• Detection Method：
• Colorimetric

• Background：
• function:Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.,PTM:Eight disulfide bonds are present.,PTM:The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.,similarity:Belongs to the folate receptor family.,tissue specificity:Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.,

• Function：
• coenzyme metabolic process, folic acid and derivative metabolic process, vitamin metabolic process, water-soluble vitamin metabolic process, amino acid transport, endocytosis, receptor-mediated endocytosis, membrane invagination,amine transport, organic acid transport, folic acid transport, membrane organization, vesicle-mediated transport,pteridine and derivative metabolic process, folic acid metabolic process, carboxylic acid transport, vitamin transport,cofactor transport, cofactor metabolic process, transmembrane transport,

• Subcellular Location：
• Cell membrane ; Lipid-anchor, GPI-anchor . Apical cell membrane ; Lipid-anchor, GPI-anchor . Basolateral cell membrane ; Lipid-anchor, GPI-like-anchor . Secreted . Cytoplasmic vesicle . Cytoplasmic vesicle, clathrin-coated vesicle . Endosome . Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. .

• Expression：
• Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.

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