• Gene Name：
• CXCL12

• Protein Name：
• Stromal cell-derived factor 1

• Human Gene Id：
• 6387

• Human Swiss Prot No：
• P48061

• Mouse Swiss Prot No：
• P40224

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• CXCL12;SDF1;SDF1A;SDF1B;Stromal cell-derived factor 1;SDF-1;hSDF-1;C-X-C motif chemokine 12;Intercrine reduced in hepatomas;IRH;hIRH;Pre-B cell growth-stimulating factor;PBSF

• Detection Method：
• Colorimetric

• Background：
• function:Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites.,online information:SDF-1 entry,PTM:Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processsed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,

• Function：
• cell morphogenesis, cell morphogenesis involved in differentiation, angiogenesis, blood vessel development,patterning of blood vessels, ameboidal cell migration, morphogenesis of a branching structure, neuron migration, cell activation, vasculature development, positive regulation of immune system process, regulation of leukocyte migration,positive regulation of leukocyte migration, regulation of leukocyte chemotaxis, positive regulation of leukocyte chemotaxis, reproductive developmental process, circulatory system process, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, cell motion, chemotaxis, immune response, cell adhesion, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, gamete generation, germ cell development, pattern specification process, axonogenesis, axon guidance, behavior, loco

• Subcellular Location：
• Secreted.

• Expression：
• Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.

Hesperidin suppresses the migration and invasion of non-small cell lung cancer cells by inhibiting the SDF-1/CXCR-4 pathway. LIFE SCIENCES 2018 Mar 29 ELISA Human A549 cell

Cancer-associated fibroblasts contribute to cancer metastasis and apoptosis resistance in human ovarian cancer via paracrine SDF-1α Clinical & Translational Oncology Li-na Yang ELISA Human Cancer-associated fibroblasts (CAFs)

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