• Gene Name：
• CORIN

• Protein Name：
• Atrial natriuretic peptide-converting enzyme

• Human Gene Id：
• 10699

• Human Swiss Prot No：
• Q9Y5Q5

• Mouse Swiss Prot No：
• Q9Z319

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• CORIN;CRN;TMPRSS10;Atrial natriuretic peptide-converting enzyme;Corin;Heart-specific serine proteinase ATC2;Pro-ANP-converting enzyme;Transmembrane protease serine 10

• Detection Method：
• Colorimetric

• Background：
• function:Converts Pro-ANP to ANP. Cleaves Pro-ANP specifically between 'Arg-123' and 'Ser-124'.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 SRCR domain.,similarity:Contains 2 FZ (frizzled) domains.,similarity:Contains 7 LDL-receptor class A domains.,tissue specificity:Highly expressed in heart. Expressed in heart myocytes.,

• Function：
• circulatory system process, proteolysis, blood circulation, regulation of blood pressure, protein processing, protein maturation, protein maturation by peptide bond cleavage,

• Subcellular Location：
• Cell membrane ; Single-pass type II membrane protein . May easily detached from the endothelial cell membrane.; [Isoform 2]: Cell membrane; Single-pass type II membrane protein. Less efficiently targeted to the cell membrane compared to isoform 1.; [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted. Soluble form produced following cleavage by ADAM10.; [Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment]: Secreted. Soluble form produced following autocatalytic cleavage.; [Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]: Secreted. Soluble form produced following autocatalytic cleavage.

• Expression：
• Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level).

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