• Gene Name：
• CHI3L1

• Protein Name：
• Chitinase-3-like protein 1

• Human Gene Id：
• 1116

• Human Swiss Prot No：
• P36222

• Mouse Swiss Prot No：
• Q61362

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• CHI3L1;Chitinase-3-like protein 1;39 kDa synovial protein;Cartilage glycoprotein 39;CGP-39;GP-39;hCGP-39;YKL-40

• Detection Method：
• Colorimetric

• Background：
• disease:A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.,function:Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.,PTM:Glycosylated.,similarity:Belongs to the glycosyl hydrolase 18 family.,subunit:Monomer.,tissue specificity:Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.,

• Function：
• polysaccharide catabolic process, polysaccharide metabolic process, aminoglycan metabolic process, aminoglycan catabolic process, chitin metabolic process, chitin catabolic process, macromolecule catabolic process, carbohydrate catabolic process,

• Subcellular Location：
• Secreted, extracellular space . Cytoplasm . Cytoplasm, perinuclear region . Endoplasmic reticulum .

• Expression：
• Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.

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