• Gene Name：
• MMP8

• Protein Name：
• Neutrophil collagenase

• Human Gene Id：
• 4317

• Human Swiss Prot No：
• P22894

• Mouse Swiss Prot No：
• O70138

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• MMP8;CLG1;Neutrophil collagenase;Matrix metalloproteinase-8;MMP-8;PMNL collagenase;PMNL-CL

• Detection Method：
• Colorimetric

• Background：
• catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Cannot be activated without removal of the activation peptide.,function:Can degrade fibrillar type I, II, and III collagens.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subcellular location:Stored in intracellular granules.,tissue specificity:Neutrophils.,

• Function：
• skeletal system development, ossification, proteolysis, collagen catabolic process, collagen metabolic process,multicellular organismal metabolic process, multicellular organismal catabolic process, multicellular organismal macromolecule metabolic process, bone development,

• Subcellular Location：
• Cytoplasmic granule. Secreted, extracellular space, extracellular matrix . Stored in intracellular granules.

• Expression：
• Neutrophils.

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