• Gene Name：
• IL6R

• Protein Name：
• Interleukin-6 receptor subunit alpha

• Human Gene Id：
• 3570

• Human Swiss Prot No：
• P08887

• Mouse Swiss Prot No：
• P22272

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• IL6R;Interleukin-6 receptor subunit alpha;IL-6 receptor subunit alpha;IL-6R subunit alpha;IL-6R-alpha;IL-6RA;IL-6R 1;Membrane glycoprotein 80;gp80;CD antigen CD126

• Detection Method：
• Colorimetric

• Background：
• domain:The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.,function:Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.,PTM:A short soluble form may also be released from the membrane by proteolysis.,similarity:Belongs to the type I cytokine receptor family. Type 3 subfamily.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subunit:Hexamer of two molecules each of IL6, IL6R and IL6ST.,tissue specificity:Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.,

• Function：
• regulation of cytokine production, negative regulation of cytokine production, positive regulation of cytokine production, regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, response to molecule of bacterial origin, organ or tissue specific immune response, immune effector process, hepatic immune response, leukocyte mediated immunity, myeloid leukocyte mediated immunity, neutrophil mediated immunity, acute inflammatory response, monocyte chemotaxis, positive regulation of immune system process, regulation of leukocyte migration, positive regulation of leukocyte migration, regulation of leukocyte chemotaxis, positive regulation of leukocyte chemotaxis, cell motion, chemotaxis, defense response, acute-phase response, inflammatory response, immune response, behavior, locomotory behavior, positive regulation of cell proliferation, res

• Subcellular Location：
• [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .; [Soluble interleukin-6 receptor subunit alpha]: Secreted .

• Expression：
• [Isoform 2]: Expressed in peripheral blood mononuclear cells and weakly found in urine and serum. 1%-20% of the total sIL6R in plasma is generated by alternative splicing (PubMed:28060820).

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