Human IL-23 ELISA Kit

  • Catalog No.：KE1143
  • Applications：ELISA
  • Reactivity：Human
    • Gene Name：
    • IL23A
    • Protein Name：
    • Interleukin-23 subunit alpha/Interleukin-12 subunit beta
    • Human Swiss Prot No：
    • Q9NPF7
    • Mouse Swiss Prot No：
    • Q9EQ14
    • Specificity：
    • Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • IL23A;SGRF;Interleukin-23 subunit alpha;IL-23 subunit alpha;IL-23-A;Interleukin-23 subunit p19;IL-23p19;IL12B;NKSF2;Interleukin-12 subunit beta;IL-12B;Cytotoxic lymphocyte maturation factor 40 kDa subunit;CLMF p40;IL-12 subunit
    • Detection Method：
    • Colorimetric
    • Background：
    • developmental stage:Expressed by newborns dendritic cells.,function:Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.,induction:Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.,similarity:Belongs to the IL-6 superfamily.,subcellular location:Secreted upon association with IL12B.,subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.,tissue specificity:Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).,
    • Function：
    • cell activation, defense response, inflammatory response, immune response, cell proliferation, response to wounding,response to virus, mononuclear cell proliferation, T cell proliferation, T cell activation, innate immune response,leukocyte activation, lymphocyte activation, lymphocyte proliferation, tissue remodeling, leukocyte proliferation,
    • Subcellular Location：
    • Secreted . Secreted upon association with IL12B.
    • Expression：
    • Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).

    Attributes

    • Code：
    • KE1143
    • Size
    • 96well / 2*96well / 5*96well
    • Price$：
    • $370 / $740 / $1,850
    • Delivery：
    • 2024-08-09
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