• Gene Name：
• IL18BP

• Protein Name：
• Interleukin-18-binding protein

• Human Gene Id：
• 10068

• Human Swiss Prot No：
• O95998

• Mouse Swiss Prot No：
• Q9Z0M9

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• IL18BP;Interleukin-18-binding protein;IL-18BP;Tadekinig-alfa

• Detection Method：
• Colorimetric

• Background：
• function:Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,tissue specificity:Strongly expressed in heart, lung, placenta and spleen.,

• Function：
• adaptive immune response, adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, immune response, T-helper 1 type immune response,

• Subcellular Location：
• Secreted .

• Expression：
• Strongly expressed in heart, lung, placenta and spleen.

Allergens elicit upregulated IL-18 and IL-18Rα expression in blood monocytes of patients with allergic rhinitis

Role of IL‐18 in atopic asthma is determined by balance of IL‐18/IL‐18BP/IL‐18R. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE J Cell Mol Med. 2018 Jan;22(1):354-373 ELISA Human plasma

Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 Receptor on Mast Cells. MEDIATORS OF INFLAMMATION Mediat Inflamm. 2017;2017:3090782 ELISA Human plasma

Altered expression of IL-18, IL-18 binding protein and IL-18 receptor in blood monocytes of patients with allergic rhinitis." (2020).

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