Human G-CSFR ELISA Kit
- Catalog No.:KE1124
- Applications:ELISA
- Reactivity:Human
- Gene Name:
- CSF3R
- Protein Name:
- Granulocyte colony-stimulating factor receptor
- Human Gene Id:
- 1441
- Human Swiss Prot No:
- Q99062
- Mouse Swiss Prot No:
- P40223
- Specificity:
- Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- CSF3R;GCSFR;Granulocyte colony-stimulating factor receptor;G-CSF receptor;G-CSF-R;CD antigen CD114
- Detection Method:
- Colorimetric
- Background:
- alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,disease:Defects in CSF3R may be a cause of severe congenital neutropenia (SCN) in some patients.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.,similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 5 fibronectin type-III domains.,subunit:Homodimer. The dimeric receptor binds two CSF3 molecules.,tissue specificity:One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U937 cells. Isoform GSCFR-3 is highly expressed in placenta.,
- Function:
- defense response, cell adhesion, biological adhesion,
- Subcellular Location:
- [Isoform 2]: Secreted .; Cell membrane ; Single-pass type I membrane protein .
- Expression:
- One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta.
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- Products Images
- The Human G-CSFR ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human G-CSFR proteins within the range of 32-2000 pg/ml.