• Gene Name：
• KITLG

• Protein Name：
• Kit ligand

• Human Gene Id：
• 4254

• Human Swiss Prot No：
• P21583

• Mouse Swiss Prot No：
• P20826

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• KITLG;MGF;SCF;Kit ligand;Mast cell growth factor;MGF;Stem cell factor;SCF;c-Kit ligand

• Detection Method：
• Colorimetric

• Background：
• developmental stage:Acts in the early stages of hematopoiesis.,function:Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins.,polymorphism:Genetic variations in KITLG are associated with variation in skin/hair/eye pigmentation type 7 (SHEP7) [MIM:611664]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair.,PTM:A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.,PTM:Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145, partially N-glycosylated at Asn-90, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118, Asn-90 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97.,similarity:Belongs to the SCF family.,subcellular location:Also exists as a secreted soluble form (isoform 1 only).,subunit:Homodimer, non-covalently linked.,

• Function：
• ameboidal cell migration, neural crest cell migration, regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, immune system development, regulation of myeloid leukocyte differentiation, positive regulation of myeloid leukocyte differentiation, regulation of DNA replication, cell motion, cell adhesion, cell proliferation, positive regulation of cell proliferation, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, mesenchymal cell development, neural crest cell development, neural crest cell differentiation, cell migration, regulation of phosphate metabolic process, biological adhesion, hemopoiesis,positive regulation of cellular biosynthetic process, regulation of protein mod

• Subcellular Location：
• [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane ; Single-pass type I membrane protein . Cell projection, lamellipodium . Cell projection, filopodium .; [Soluble KIT ligand]: Secreted.

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