• Gene Name：
• IL1A

• Protein Name：
• Interleukin-1 alpha

• Human Gene Id：
• 3552

• Human Swiss Prot No：
• P01583

• Mouse Swiss Prot No：
• P01582

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• IL1A;IL1F1;Interleukin-1 alpha;IL-1 alpha;Hematopoietin-1

• Detection Method：
• Colorimetric

• Background：
• domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.,function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the IL-1 family.,subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.,subunit:Monomer.,

• Function：
• temperature homeostasis, fever, regulation of cytokine production, positive regulation of cytokine production, acute inflammatory response, apoptosis, anti-apoptosis, defense response, acute-phase response, inflammatory response,immune response, regulation of mitosis, regulation of mitotic cell cycle, cell death, cell proliferation, negative regulation of cell proliferation, response to wounding, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, regulation of cell cycle process, regulation of vascular endothelial growth factor production, positive regulation vascular endothelial growth factor production, positive regulation of macromolecule metabolic process, positive regulation of organelle organization, regulation of cell death, programmed cell death,death, cytokine-mediated signaling pathway, positive regulation of cellular biosynt

• Subcellular Location：
• Cytoplasm . Secreted . The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .

RIPK1 regulates cell function and death mediated by UVB radiation and TNF-α. MOLECULAR IMMUNOLOGY Mol Immunol. 2021 Jul;135:304 ELISA Human HaCaT cell

CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH J Exp Clin Canc Res. 2019 Dec;38(1):1-18 ELISA Mouse serum

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