• Gene Name：
• FST

• Protein Name：
• Follistatin

• Human Gene Id：
• 10468

• Human Swiss Prot No：
• P19883

• Mouse Swiss Prot No：
• P47931

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• FST;Follistatin;FS;Activin-binding protein

• Detection Method：
• Colorimetric

• Background：
• function:Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).,similarity:Contains 1 TB (TGF-beta binding) domain.,similarity:Contains 3 follistatin-like domains.,similarity:Contains 3 Kazal-like domains.,subunit:Monomer .,tissue specificity:Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.,

• Function：
• negative regulation of transcription from RNA polymerase II promoter, hair follicle development, reproductive developmental process, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway,transmembrane receptor protein serine/threonine kinase signaling pathway, gamete generation, pattern specification process, ectoderm development, sex differentiation, cell proliferation, gonad development, epidermis development,female gonad development, negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, negative regulation of transcription, sexual reproduction, molting cycle process, hair cycle process, BMP sig

• Subcellular Location：
• Secreted.

• Expression：
• Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme (PubMed:31215115).

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