• Gene Name：
• CTGF

• Protein Name：
• Connective tissue growth factor

• Human Gene Id：
• 1490

• Human Swiss Prot No：
• P29279

• Mouse Swiss Prot No：
• P29268

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• CTGF;CCN2;HCS24;IGFBP8;Connective tissue growth factor;CCN family member 2;Hypertrophic chondrocyte-specific protein 24;Insulin-like growth factor-binding protein 8;IBP-8;IGF-binding protein 8;IGFBP-8

• Detection Method：
• Colorimetric

• Background：
• function:Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.,similarity:Belongs to the CCN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 1 VWFC domain.,subunit:Monomer.,

• Function：
• skeletal system development, cartilage condensation, ossification, angiogenesis, regulation of cell growth, blood vessel development, vasculature development, DNA metabolic process, DNA replication, cell motion, cell adhesion, cell-matrix adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway,transmembrane receptor protein tyrosine kinase signaling pathway, integrin-mediated signaling pathway, intracellular signaling cascade, ectoderm development, fibroblast growth factor receptor signaling pathway, epidermis development, response to wounding, cell-cell adhesion, cell migration, biological adhesion, respiratory tube development, lung development, cell-substrate adhesion, tube development, regulation of growth, blood vessel morphogenesis, skeletal system morphogenesis, cell motility, cartilage development, localization of cell, bone de

• Subcellular Location：
• Secreted, extracellular space, extracellular matrix . Secreted .

• Expression：
• Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.

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