Cytokeratin 20 (ABT044) IHC kit

    • Catalog No.:IHCM6866
    • Applications:IHC
    • Reactivity:Human; Mouse (predicted: Rat)
      • Target:
      • Cytokeratin 20
      • Fields:
      • >>Estrogen signaling pathway;>>Staphylococcus aureus infection
      • Gene Name:
      • KRT20
      • Protein Name:
      • Cytokeratin-20
      • Human Swiss Prot No:
      • P35900
      • Immunogen:
      • Synthesized peptide derived from human CK20 AA range: 300-424
      • Specificity:
      • The antibody can specifically recognize human CK20 protein, and shows no cross reaction with CK1, 5, 6, 7, 8, 13, 14, 15, 17, 18.
      • Source:
      • Mouse, Monoclonal/IgG2b, Kappa
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Storage Stability:
      • 2°C to 8°C/1 year
      • Other Name:
      • Keratin, type I cytoskeletal 20 (Cytokeratin-20;CK-20;Keratin-20;K20;Protein IT)
      • Background:
      • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008],
      • Function:
      • developmental stage:First detected at embryonic week 8 in individual 'converted' simple epithelial cells of the developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number of villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells as well as certain 'low-differentiated' columnar cells, whereas the neuroendocrine and Paneth cells are negative.,function:Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during t
      • Subcellular Location:
      • Cytoplasmic, Membranous
      • Expression:
      • Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.
      • Products Images
      • Human appendix tissue was stained with Anti-Cytokeratin 20 (ABT044) Antibody
      • Human colon carcinoma tissue was stained with Anti-Cytokeratin 20 (ABT044) Antibody
      • Human rectal carcinoma tissue was stained with Anti-Cytokeratin 20 (ABT044) Antibody