CD35 (ABT-CD35) IHC kit
- Catalog No.:IHCM6280
- Applications:IHC
- Reactivity:Human;
- Target:
- CD35
- Fields:
- >>Complement and coagulation cascades;>>Neutrophil extracellular trap formation;>>Hematopoietic cell lineage;>>Legionellosis;>>Leishmaniasis;>>Malaria;>>Tuberculosis
- Gene Name:
- CR1 C3BR
- Protein Name:
- Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)
- Human Gene Id:
- 1378
- Human Swiss Prot No:
- P17927
- Immunogen:
- Synthesized peptide derived from human CD35 AA range: 300-400
- Specificity:
- The antibody can specifically recognize human CD35 protein.
- Source:
- Mouse, Monoclonal/IgG1, kappa
- Purification:
- The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
- Storage Stability:
- 2°C to 8°C/1 year
- Background:
- This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants
- Function:
- function:Mediates cellular binding of particles and immune complexes that have activated complement.,miscellaneous:This is the sequence of the F allotype of CR1.,online information:Blood group antigen gene mutation database,polymorphism:CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien). Sl(a-) phenotype is more common in persons of African descent and may protect against fatal malaria.,similarity:Belongs to the receptors of complement activation (RCA) family.,similarity:Contains 30 Sushi (CCP/SCR) domains.,subunit:Monomer.,tissue specificity:Present on erythrocytes, leukocytes, glomerular podo
- Subcellular Location:
- Membranous
- Expression:
- Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes.
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- Antibody-FAQs
- Products Images
- Human kidney tissue was stained with Anti-CD35 (ABT-CD35) Antibody
- Human liver tissue was stained with Anti-CD35 (ABT-CD35) Antibody
- Human tonsil tissue was stained with Anti-CD35 (ABT-CD35) Antibody