• Target：
• CD74

• Fields：
• >>Antigen processing and presentation;>>Tuberculosis;>>Herpes simplex virus 1 infection

• Gene Name：
• CD74 DHLAG

• Protein Name：
• CD74

• Human Gene Id：
• 972

• Human Swiss Prot No：
• P04233

• Immunogen：
• Synthesized peptide derived from human CD74 AA range: 150-250

• Specificity：
• This antibody detects endogenous levels of CD74 protein.

• Source：
• Mouse, Monoclonal/IgG2a, kappa

• Purification：
• The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

• Storage Stability：
• 2°C to 8°C/1 year

• Other Name：
• CD 74 antibody;CD74 antibody;CD74 antigen (invariant polypeptide of major histocompatibility complex; class II antigen-associated) antibody;CD74 antigen antibody;CD74 molecule antibody;CD74 molecule; major histocompatibility complex; class II invariant chain antibody;CLIP antibody;DHLAG antibody;Gamma chain of class II antigens antibody;HG2A_HUMAN antibody;HLA class II histocompatibility antigen gamma chain antibody;HLA DR antigens associated invariant chain antibody;HLA DR gamma antibody;HLA-DR antigens-associated invariant chain antibody;HLA-DR-gamma antibody;HLADG antibody;HLADR antigens associated invariant chain antibody;Ia antigen associated invariant chain antibody;Ia antigen-associated invariant chain antibody;Ia associated invariant chain antibody;Ia gamma antibody;Ii antibody;Invariant polypeptide of major histocompatibility complex class II antigen associated antibody;la-gamma antibody;Major histocompatibility complex class II invariant chain antibody;MHC HLA DR gamma chain

• Background：
• The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],

• Function：
• function:Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Nonamer composed of three alpha/beta/gamma heterotrimers.,

• Subcellular Location：
• Membranous

• Expression：
• [Isoform p41]: In B cells, represents 10% of total CD74 expression. ; [Isoform p33]: In B cells, represents 70% of total CD74 expression.

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