• Target：
• LX15B

• Fields：
• >>Arachidonic acid metabolism;>>Metabolic pathways;>>Serotonergic synapse

• Gene Name：
• ALOX15B

• Protein Name：
• LX15B

• Human Gene Id：
• 247

• Human Swiss Prot No：
• O15296

• Mouse Gene Id：
• 11688

• Mouse Swiss Prot No：
• O35936

• Rat Gene Id：
• 266604

• Rat Swiss Prot No：
• Q8K4F2

• Immunogen：
• Synthesized peptide derived from human LX15B AA range: 576-626

• Specificity：
• This antibody detects endogenous levels of LX15B at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 74kD

• Background：
• This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.,cofactor:Binds 1 iron ion per subunit.,function:Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized.,pathway:Lipid metabolism; leukotriene D4 biosynthesis.,similarity:Belongs to the lipoxygenase family.,similarity:Contains 1 lipoxygenase domain.,similarity:Contains 1 PLAT domain.,tissue specificity:Expressed in hair, prostate, lung and cornea.,

• Subcellular Location：
• [Isoform A]: Nucleus . Other isoforms are excluded from the nucleus. .; Cytoplasm, cytosol . Cell membrane . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cell junction, adherens junction . Cell junction, focal adhesion . Predominantly cytosolic; becomes enriched at membranes upon calcium binding. .

• Expression：
• Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea.

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