• Target：
• ASCC3

• Gene Name：
• ASCC3 HELIC1

• Protein Name：
• ASCC3

• Human Gene Id：
• 10973

• Human Swiss Prot No：
• Q8N3C0

• Mouse Gene Id：
• 77987

• Mouse Swiss Prot No：
• E9PZJ8

• Rat Swiss Prot No：
• F1LPQ2

• Immunogen：
• Synthesized peptide derived from human ASCC3 AA range: 2053-2103

• Specificity：
• This antibody detects endogenous levels of ASCC3 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 242kD

• Background：
• This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],

• Function：
• function:Enhances NF-kappa-B, SRF and AP1 transactivation.,similarity:Belongs to the helicase family.,similarity:Contains 2 helicase ATP-binding domains.,similarity:Contains 2 helicase C-terminal domains.,similarity:Contains 3 SEC63 domains.,subunit:Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3.,tissue specificity:Ubiquitous.,

• Subcellular Location：
• Nucleus . Nucleus speckle . Cytoplasm, cytosol . Colocalizes with ALKBH3 and ASCC2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. .

• Expression：
• Ubiquitous.

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