• Target：
• DCK

• Fields：
• >>Purine metabolism;>>Pyrimidine metabolism;>>Metabolic pathways;>>Nucleotide metabolism

• Gene Name：
• DCK

• Protein Name：
• DCK

• Human Gene Id：
• 1633

• Human Swiss Prot No：
• P27707

• Mouse Gene Id：
• 13178

• Mouse Swiss Prot No：
• P43346

• Rat Gene Id：
• 79127

• Rat Swiss Prot No：
• P48769

• Immunogen：
• Synthesized peptide derived from human DCK AA range: 62-112

• Specificity：
• This antibody detects endogenous levels of DCK at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 29kD

• Background：
• Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:NTP + deoxycytidine = NDP + dCMP.,function:Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DCK/DGK family.,subunit:Homodimer.,

• Subcellular Location：
• Nucleus .

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