• Target：
• MTDC

• Fields：
• >>One carbon pool by folate;>>Metabolic pathways;>>Biosynthesis of cofactors

• Gene Name：
• MTHFD2 NMDMC

• Protein Name：
• MTDC

• Human Gene Id：
• 10797

• Human Swiss Prot No：
• P13995

• Mouse Gene Id：
• 17768

• Mouse Swiss Prot No：
• P18155

• Immunogen：
• Synthesized peptide derived from human MTDC AA range: 121-171

• Specificity：
• This antibody detects endogenous levels of MTDC at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 39kD

• Background：
• This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009],

• Function：
• catalytic activity:5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.,catalytic activity:5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.,cofactor:Magnesium.,developmental stage:Expressed only in developing normal tissues.,miscellaneous:This NAD-dependent bifunctional enzyme has very different kinetic properties than the larger NADP-dependent trifunctional enzyme and is unique in that it requires formation of an enzyme-magnesium complex to allow binding of NAD.,similarity:Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.,subunit:Homodimer.,

• Subcellular Location：
• Mitochondrion.

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