CACB1 rabbit pAb
- Catalog No.:YT6675
- Applications:WB
- Reactivity:Human;Mouse;Rat
- Target:
- CACB1
- Fields:
- >>MAPK signaling pathway;>>Cardiac muscle contraction;>>Adrenergic signaling in cardiomyocytes;>>Oxytocin signaling pathway;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy
- Gene Name:
- CACNB1 CACNLB1
- Protein Name:
- CACB1
- Human Gene Id:
- 782
- Human Swiss Prot No:
- Q02641
- Mouse Gene Id:
- 12295
- Mouse Swiss Prot No:
- Q8R3Z5
- Rat Gene Id:
- 50688
- Rat Swiss Prot No:
- P54283
- Immunogen:
- Synthesized peptide derived from human CACB1 AA range: 79-129
- Specificity:
- This antibody detects endogenous levels of CACB1 at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 66kD
- Background:
- The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008],
- Function:
- function:The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.,similarity:Belongs to the calcium channel beta subunit family.,similarity:Contains 1 SH3 domain.,subunit:The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with JSRP1.,tissue specificity:Expressed in brain, heart and spleen (isoform 1 and 3) and in skeletal muscle (isoform 2).,
- Subcellular Location:
- Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein .
- Expression:
- Detected in heart ventricle (at protein level) (PubMed:15615847). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night