• Target：
• PDLI3

• Gene Name：
• PDLIM3 ALP

• Protein Name：
• PDLI3

• Human Gene Id：
• 27295

• Human Swiss Prot No：
• Q53GG5

• Mouse Gene Id：
• 53318

• Mouse Swiss Prot No：
• O70209

• Rat Gene Id：
• 114108

• Rat Swiss Prot No：
• Q66HS7

• Immunogen：
• Synthesized peptide derived from human PDLI3 AA range: 251-301

• Specificity：
• This antibody detects endogenous levels of PDLI3 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 40kD

• Background：
• The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012],

• Function：
• disease:Quantitative or qualitative alterations of expression have not been detected in facioscapulohumeral muscular dystrophy (FSHD).,function:May play a role in the organization of actin filament arrays within muscle cells.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Localizes to myofiber Z-lines.,subunit:Interacts with ACTN2.,tissue specificity:Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.,

• Subcellular Location：
• Cytoplasm, myofibril, sarcomere, Z line . Localizes to myofiber Z-lines.

• Expression：
• Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.

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